Furthermore, intact epidermal cysts exhibit branching telangiectasia, whereas ruptured ones display peripheral, linear, and branched vessels (45). The dermoscopic appearance of steatocystoma multiplex, as well as milia, is characterized by a peripheral brown ring, linear vessels within the lesion, and a uniform yellow backdrop encompassing the entire affected area, according to reference (5). Distinguishing characteristics of cystic lesions, especially those noted previously, are linear vessels in other cases, whereas pilonidal cysts exhibit distinctive dotted, glomerular, and hairpin-shaped vessels. Pilonidal cyst disease, along with amelanotic melanoma, basal cell carcinoma, squamous cell carcinoma, pyogenic granuloma, lymphoma, and pseudolymphoma, warrants consideration within the differential diagnosis of pink nodular lesions (3). A pink background, central ulceration, peripherally arranged dotted vessels, and white lines are seemingly prevalent dermoscopic characteristics of pilonidal cyst disease, as observed in our cases and two previously reported cases. Our observations on pilonidal cyst disease show that dermoscopically, central, yellowish, structureless areas, alongside peripheral hairpin and glomerular vessels, are present. Finally, the aforementioned dermoscopic traits readily differentiate pilonidal cysts from other cutaneous masses, and dermoscopy can corroborate a clinical suspicion of pilonidal cyst. To more thoroughly characterize the typical dermoscopic signs of this disease and their frequency, additional research is required.

Dear Editor, in the English medical literature, the uncommon condition of segmental Darier disease (DD) has been reported in about 40 instances. One proposed cause of the disease is a post-zygotic somatic mutation in the calcium ATPase pump, which is localized exclusively to lesional skin. Blaschko's lines dictate the placement of lesions in segmental DD type 1, which is unilateral; segmental DD type 2, meanwhile, in individuals with generalized DD, is notable for intensely affected focal regions (1). Type 1 segmental DD presents a diagnostic hurdle owing to the absence of a positive family history, the disease's delayed emergence during the third or fourth decade, and the lack of identifiable DD-related characteristics. A differential diagnosis for type 1 segmental DD involves acquired papular dermatoses, including lichen planus, psoriasis, lichen striatus, or linear porokeratosis, often arranged in linear or zosteriform patterns (2). A report of two cases of segmental DD is presented, the first being a 43-year-old female patient, who experienced pruritic skin changes that persisted for five years, with a history of worsening symptoms during allergy seasons. The left abdominal and inframammary regions exhibited a swirling array of small, keratotic papules, light brownish to reddish in hue, as observed during the examination (Figure 1a). Figure 1, panel b, displays dermoscopic findings of polygonal or roundish yellowish-brown areas encircled by whitish, structureless regions. Impending pathological fractures The histopathological correlation between dermoscopic brownish polygonal or round areas and the presence of hyperkeratosis, parakeratosis, and dyskeratotic keratinocytes in the biopsy specimen (Figure 1, c) is noteworthy. A 0.1% tretinoin gel prescription yielded a substantial improvement for the patient, as illustrated in Figure 1, panel d. A zosteriform rash comprising small red-brown papules, eroded papules, and yellow crusts appeared on the right upper abdomen of a 62-year-old woman, forming the second case (Figure 2a). Polygonal, roundish, yellowish areas, encompassed by a border of structureless whitish and reddish pigmentation, were observed by dermoscopy (Figure 2b). In the histopathological assessment, compact orthokeratosis was prevalent, along with small parakeratosis foci. The marked granular layer contained dyskeratotic keratinocytes and displayed foci of suprabasal acantholysis, consistent with a diagnosis of DD (Figure 2, d, d). The patient's condition showed improvement after receiving a prescription of 0.1% adapalene cream and topical steroid cream. In both our cases, clinico-histopathologic analysis established a conclusive diagnosis of type 1 segmental DD, since acantholytic dyskeratotic epidermal nevus, clinically and histologically similar to segmental DD, was not ruled out by histopathology alone. A diagnosis of segmental DD was supported by the delayed onset and worsening symptoms attributed to external factors like heat, sunlight, and sweat. While clinical and histopathological observations typically confirm the type 1 segmental DD diagnosis, dermoscopy proves indispensable in the diagnostic process by reducing alternative diagnoses, while paying attention to their characteristic dermoscopic patterns.

Condyloma acuminatum, whilst seldom found in the urethra, is predominantly confined to its most distal segment if it is present. Various treatment options for urethral condylomas have been reported in the literature. Extensive and variable treatments consist of laser treatment, electrosurgery, cryotherapy, and topical applications of cytotoxic agents like 80% trichloroacetic acid, 5-fluorouracil cream (5-FU), podophyllin, podophyllotoxin, and imiquimod. Laser therapy persists as the primary treatment modality for intraurethral condylomata. A 25-year-old male patient with meatal intraurethral warts, after facing repeated failure with treatments including laser, electrosurgery, cryotherapy, imiquimod, and 80% trichloroacetic acid, was ultimately cured with 5-FU.

Erythroderma and generalized scaling serve as hallmarks of a heterogeneous group of skin disorders, ichthyoses. The interplay of ichthyosis and melanoma in the human body is not yet well-documented. In this instance, we describe a distinct case of palmar acral melanoma affecting a senior individual with a history of congenital ichthyosis vulgaris. A superficial spreading melanoma, evidenced by ulceration, was detected through biopsy. In the patients with congenital ichthyosis, no cases of acral melanomas have been observed, as far as we are aware. Although ichthyosis vulgaris is a factor, the risk of melanoma infiltration and spread compels regular clinical and dermatoscopic screenings for patients.

We present a case study of penile squamous cell carcinoma (SCC) in a 55-year-old male. presymptomatic infectors A gradual increase in size characterized the mass found in the patient's penis. A portion of the penis was surgically removed to address the mass, through a partial penectomy. Upon microscopic examination, a well-differentiated squamous cell carcinoma was identified. The polymerase chain reaction process identified human papillomavirus (HPV) DNA. The squamous cell carcinoma's HPV presence, identified as type 58, was confirmed through sequencing.

The simultaneous presence of skin and non-skin anomalies is a typical presentation of various genetic syndromes, extensively reported in medical literature. Nevertheless, the possibility of undiscovered and unnamed symptom combinations persists. 5-Fluorouracil research buy The Dermatology Department received a patient with multiple basal cell carcinomas, the source of which was a nevus sebaceous, a case report we present here. The patient's presentation included cutaneous malignancies, palmoplantar keratoderma, prurigo nodularis, hypothyroidism, multiple lumbar abnormalities, a uterine myoma, an ovarian cyst, and a highly dysplastic colon adenoma. Multiple disorders occurring together might indicate a genetic etiology of the diseases.

Drug exposure triggers the inflammatory process in small blood vessels, ultimately causing drug-induced vasculitis and potential damage to the affected tissue. The medical literature has noted rare instances of vasculitis that can be a side effect of chemotherapy, or when combined with radiotherapy. A medical diagnosis of small cell lung cancer (SCLC), stage IIIA (cT4N1M0), was confirmed in our patient's case. Four weeks post-administration of the second course of carboplatin and etoposide (CE) chemotherapy, the patient presented with a rash and cutaneous vasculitis primarily affecting the lower extremities. CE chemotherapy was ceased, and symptomatic relief was provided through methylprednisolone administration. The prescribed corticosteroid treatment protocol exhibited a beneficial effect on the local presentations. Post chemo-radiotherapy completion, the patient's treatment continued with a consolidation chemotherapy regimen of four cycles, employing cisplatin, for a total of six chemotherapy cycles. Further regression of the cutaneous vasculitis was observed during the clinical evaluation. Elective radiotherapy of the brain was carried out in the post-consolidation chemotherapy phase. Until the disease returned, the patient was monitored clinically. Subsequent chemotherapy regimens were delivered to address the platinum-resistant disease. Sadly, the patient's life ended seventeen months after receiving an SCLC diagnosis. This case, to our best knowledge, constitutes the first instance of lower extremity vasculitis in a patient undergoing concurrent radiotherapy and CE chemotherapy, forming part of the initial treatment regimen for small cell lung cancer.

Amongst dentists, printers, and fiberglass workers, allergic contact dermatitis (ACD) stemming from (meth)acrylates has historically been a prevalent occupational affliction. Cases of health concerns, stemming from the use of artificial nails, have been recorded, involving both nail technicians and those wearing them. The use of (meth)acrylates in artificial nails, leading to ACD, presents a significant concern for both nail technicians and customers. Following two years of employment as a nail technician, a 34-year-old woman displayed severe hand dermatitis, primarily on her fingertips, in conjunction with frequent occurrences of facial dermatitis. Artificial nails, a four-month solution to the patient's frequently splitting nails, have been complemented by regular gel applications for added protection. Her asthma manifested in several episodes while she was working at her workplace. To establish a baseline, a patch test was applied to the baseline series, the acrylate series, and the patient's own material.